All the patients include 75 patients with urticaria, 27 patients with eczema and 79 patients with allergic dermatitis
All the patients include 75 patients with urticaria, 27 patients with eczema and 79 patients with allergic dermatitis. to food-specific IgG antibody and the allergy dermatoses patients have a high incidence rate of food intolerance; detecting IgG antibody in patients is usually of great significance for the diagnosis and treatment of allergy dermatoses. strong class=”kwd-title” Keywords: food-specific IgG antibody, allergy dermatoses, food intolerance 1 Introduction Allergy dermatosis is an inflammatory dermatosis caused by allergic reaction, featuring complicated causes, uncertain pathogenesis and high recurrence rate [1C3]. Allergy dermatoses are mainly caused by allergen, which can lead to inflammatory reaction through ingesting and touching [4,5]. Research [7,8] shows that as many as 40% of people have tolerance against some food to some degrees and food intolerance can cause allergy dermatoses. In the mean time, clinical data  show that IgG antibody detection is closely related to adverse reactions to food and the studies on allergy dermatoses involved in IgG have been paid increasing attention. This GSK2110183 analog 1 test conducted the detection of food-specific IgG antibody in the serum of allergy dermatosis patients to explore its application in allergy dermatoses. Now the statement will be stated as follows. 2 Data and methods 2.1 General data 181 allergy dermatosis patients who were diagnosed in dermatological department of our hospital from January 2014 to September 2014 were determined including 98 males and 83 females at the age ranging from 2 months to 73 years old. All the patients include 75 patients with urticaria, 27 patients with eczema and 79 patients with allergic dermatitis. There were also 20 healthy subjects of 11 males and 9 females who participated and experienced no significant difference on age and gender with patient group. Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional guidelines and in accordance the tenets of the Helsinki Declaration, and has been approved by the authors institutional evaluate board or comparative committee. Informed consent: Informed consent has been obtained from all individuals included in this study. 2.2 Methods 2 ml program venous blood was collected (Fasting is not necessary). The food intolerance detection packages of BIOMERICA Organization of America and the ELISA method were used to detect the specific antibody IgG in 14 kinds of foods including shrimp, crab, cod, beef, pork, chicken, egg, milk, wheat, corn, rice, tomato, soybean and mushroom. On the basis of the result, the standard of mild, CACNLG moderate and severe can be decided according to the different IgG antibody concentration of different foods. For details observe Table 1. Table 1 Identifying standard of food intolerance. thead th valign=”top” align=”left” rowspan=”1″ colspan=”1″ IgG(U/ml) /th th valign=”top” align=”left” rowspan=”1″ colspan=”1″ Level /th th valign=”top” align=”left” rowspan=”1″ colspan=”1″ Identifying Standard /th /thead 500Feminine50C100+1Mild Intolerance100C200+2Moderate Intolerance 200+3Severe Intolerance Open in a separate windows 2.3 Statistical method All the data are input in the form of EXCEL and the statistical software SPSS18.0 is used to analyze these data. Wherein, the count data are tested by Chi-square test and when p 0.05, the difference has statistical significance. 3 Result 3.1 Positive rates of IgG antibody of healthy subjects and allergy dermatosis patients Among 20 healthy subjects, 1 subject tested positive for IgG antibody, which translates to a positive rate was 5.0%. Among 181 patients with allergy dermatoses, 118 patients tested positive for IgG antibody with a total positive rate GSK2110183 analog 1 was 65.2%. There was a significant difference in the positive rate of IgG antibody of healthy GSK2110183 analog 1 group, yet not for the patient group (X2=71.8,p 0.05); Observe Figure GSK2110183 analog 1 1. There was no significant difference in the positive rate of IgG antibody among urticaria, eczema and allergic dermatitis groups(p 0.05). For details see Table 2. Open in a separate windows Physique 1 Comparison of IgG antibody positive rate between healthy subjects and patients. Table 2 Comparison of IgG antibody positive rate between healthy group and allergy dermatosis group. thead th valign=”top” align=”left” rowspan=”1″ colspan=”1″ Groups /th th valign=”top” align=”left” rowspan=”1″ colspan=”1″ n /th th valign=”top” align=”left” rowspan=”1″ colspan=”1″ Positive Cases /th th.