A total of 1 1 106/ml CD4+ T cells were stimulated with anti-CD3/28 antibody-coated beads (the ratio of bead and cell is 1?:?1; Invitrogen) for 3 or 4 4 days. sphingomyelinase (ASM), a lipid hydrolase enzyme localized to lysosomes and cell membranes, converts sphingomyelin to ceramide,1 an important lipid messenger mediating cell signaling.2, 3 Through the generation of ceramide, ASM […]

The difference within the mean values among treatment groups towards the controls were analyzed by a proven way analysis of variance. Abbreviations CLL: Chronic lymphocytic leukemia; PBMC: Peripheral bloodstream mononuclear cell; HMG-CoA: Hydroxy-3-methylglutaryl-coenzyme A. Competing interests The authors declare they have no competing interests. Authors’ contributions IB, CF, and CH conceived the experimental style. or their combos. Results We discovered […]